Supratherapeutic oseltamivir levels during continuous dialysis: an expected risk
نویسندگان
چکیده
منابع مشابه
Continuous mortality risk among peritoneal dialysis patients.
C onventional hemodialysis (CHD) administered thrice weekly for 3to 4-hour sessions and peritoneal dialysis (PD) are the 2 most commonly delivered dialysis modalities. Patients treated with CHD are subject to short periods of rapid fluid and solute removal accompanied by brisk electrolyte shifts followed by long intervals when these substances reaccumulate. In contrast, PD uses the patient’s pe...
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The pharmacokinetics of amikacin were investigated in five stable patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Each patient was studied after the administration of 7.5 mg of amikacin per kg by both the intravenous (i.v.) and intraperitoneal (i.p.) route, allowing a 1-month washout period between doses. No differences in amikacin half-life, volume of distribution, total ...
متن کاملThe pharmacokinetics and tolerability of oseltamivir suspension in patients on haemodialysis and continuous ambulatory peritoneal dialysis.
BACKGROUND Oseltamivir dose reduction is recommended for patients with end-stage renal disease (ESRD). However, dosing recommendations are not available for treatment or prophylaxis of influenza in these patients. This study assessed the pharmacokinetics and tolerability of oseltamivir in ESRD patients undergoing maintenance haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD...
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A continuous-flow synthesis of (–)-oseltamivir composed of five flow units was accomplished. In each unit, the following reactions proceed efficiently: (1) a diphenylprolinol silyl ether mediated Michael reaction, (2) a domino reaction of Michael and intermolecular Horner– Wadsworth–Emmons reactions, (3) protonation, (4) epimerization, and (5) reduction of a nitro group to an amine. (–)-Oseltam...
متن کاملOptimising risk reduction: An expected utility approach for marginal risk reduction during regulatory decision making
In practice, risk and uncertainty are essentially unavoidable in many regulation processes. Regulators frequently face a risk-benefit trade-off since zero risk is neither practicable nor affordable. Although it is accepted that cost–benefit analysis is important in many scenarios of risk management, what role it should play in a decision process is still controversial. One criticism of cost–ben...
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ژورنال
عنوان ژورنال: Intensive Care Medicine
سال: 2010
ISSN: 0342-4642,1432-1238
DOI: 10.1007/s00134-010-2080-5